Reaction Structure Profile: A Comparative Analysis of Metabolic Pathways Based on Important Substructures

• Item type: Trans(1)
• 公開日: 2008-03-15
• タイトル: Reaction Structure Profile: A Comparative Analysis of Metabolic Pathways Based on Important Substructures
• タイトル / 言語: en
• タイトル: Reaction Structure Profile: A Comparative Analysis of Metabolic Pathways Based on Important Substructures
• 言語: eng
• キーワード / 主題Scheme: Other
• キーワード / 主題: Original Papers
• 資源タイプ / 資源タイプ識別子: http://purl.org/coar/resource_type/c_6501
• 資源タイプ: journal article
• 著者所属: Graduate School of Engineering Kobe University
• 著者所属: Organization of Advanced Science and Technology Kobe University
• 著者所属: Graduate School of Engineering Kobe University
• 著者所属(英): en
• 著者所属(英): Graduate School of Engineering, Kobe University
• 著者所属(英): en
• 著者所属(英): Organization of Advanced Science and Technology,Kobe University
• 著者所属(英): en
• 著者所属(英): Graduate School of Engineering, Kobe University
• 著者名: Yuta, Ashida; Tomonobu, Ozaki; Takenao, Ohkawa
• 著者名(英): Yuta, Ashida; Tomonobu, Ozaki; Takenao, Ohkawa
• 論文抄録 / 内容記述タイプ: Other
• 論文抄録 / 内容記述: Comparative analysis of organisms with metabolic pathways gives important information about functions within organisms. In this paper we propose a new method for comparing the metabolic pathways with reaction structures that include important enzymes. In this method subgraphs from pathways that include ‘choke point’ or ‘load point’ are extracted as important “reaction structures ” and a “reaction structure profile ” which represents whether extracted reaction structures are observed in the metabolic pathway of other organisms is created. Distance regarding function within organisms between species is defined using the“reaction structure profile.” By applying the proposed method to the metabolic networks of 64 representative organisms selected from Archaea Eubacteria and Eukaryote in the KEGG database we succeed in reconstructing a phylogenetic tree and confirm the effectiveness of the method.
• 論文抄録(英) / 内容記述タイプ: Other
• 論文抄録(英) / 内容記述: Comparative analysis of organisms with metabolic pathways gives important information about functions within organisms. In this paper, we propose a new method for comparing the metabolic pathways with reaction structures that include important enzymes. In this method, subgraphs from pathways that include ‘choke point’ or ‘load point’ are extracted as important “reaction structures,” and a “reaction structure profile,” which represents whether extracted reaction structures are observed in the metabolic pathway of other organisms, is created. Distance regarding function within organisms between species is defined using the“reaction structure profile.” By applying the proposed method to the metabolic networks of 64 representative organisms selected from Archaea, Eubacteria and Eukaryote in the KEGG database, we succeed in reconstructing a phylogenetic tree, and confirm the effectiveness of the method.
• 書誌レコードID / 収録物識別子タイプ: NCID
• 書誌レコードID / 収録物識別子: AA12177013
• 書誌情報: IPSJ Transactions on Bioinformatics （TBIO）; 巻 49, 号 SIG5(TBIO4), p. 36-45, 発行日 2008-03-15
• ISSN / 収録物識別子タイプ: ISSN
• ISSN / 収録物識別子: 1882-6679
• 出版者 / 言語: ja
• 出版者: 情報処理学会