{"updated":"2025-01-21T14:49:34.997445+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00092665","sets":["1164:5352:7133:7203"]},"path":["7203"],"owner":"11","recid":"92665","title":["局所脳冷却のてんかん発作抑制メカニズムの解明に向けたシミュレーション"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-20"},"_buckets":{"deposit":"faa20701-a65d-4d79-b814-aec39d0541b2"},"_deposit":{"id":"92665","pid":{"type":"depid","value":"92665","revision_id":0},"owners":[11],"status":"published","created_by":11},"item_title":"局所脳冷却のてんかん発作抑制メカニズムの解明に向けたシミュレーション","author_link":["0","0"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"局所脳冷却のてんかん発作抑制メカニズムの解明に向けたシミュレーション"},{"subitem_title":"Understanding the Seizure-Suppressing Mechanism of Focal Brain Cooling through Simulation","subitem_title_language":"en"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"一般（ＮＣ）","subitem_subject_scheme":"Other"}]},"item_type_id":"4","publish_date":"2013-06-20","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"奈良先端科学技術大学院大学情報科学研究科"},{"subitem_text_value":"奈良先端科学技術大学院大学情報科学研究科"},{"subitem_text_value":"静岡大学工学部"},{"subitem_text_value":"奈良先端科学技術大学院大学情報科学研究科"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Information Science, Nara Institute of Science and Technology","subitem_text_language":"en"},{"subitem_text_value":"Graduate School of Information Science, Nara Institute of Science and Technology","subitem_text_language":"en"},{"subitem_text_value":"Faculty of Engineering, Shizoka University","subitem_text_language":"en"},{"subitem_text_value":"Graduate School of Information Science, Nara Institute of Science and Technology","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/92665/files/IPSJ-BIO13034023.pdf"},"date":[{"dateType":"Available","dateValue":"2100-01-01"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-BIO13034023.pdf","filesize":[{"value":"534.9 kB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"0","billingrole":"41"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"9e439467-1331-4916-9b0d-acbdfb86dfc5","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2013 by the Institute of Electronics, Information and Communication Engineers\nThis SIG report is only available to those in membership of the SIG."}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山村, 頼子"},{"creatorName":"久保, 孝富"},{"creatorName":"山川, 俊貴"},{"creatorName":"池田, 和司"}],"nameIdentifiers":[{}]}]},"item_4_creator_6":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YorikoYamamura","creatorNameLang":"en"},{"creatorName":"Takatomi, Kubo","creatorNameLang":"en"},{"creatorName":"Toshitaka, Yamakawa","creatorNameLang":"en"},{"creatorName":"Kazushi, Ikeda","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12055912","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"局所脳冷却には，てんかん発作を抑制する効果があることが知られている．このことから，局所脳冷却の埋め込み型てんかん抑制装置への応用が期待されている．しかし，局所脳冷却がてんかん発作を抑制するメカニズムは未だ明らかになっていない．本研究では，温度依存的に反応速度が変化する Hodgkin-HuxIey 型イオンチャネルモデルを用いて新皮質の神経ネットワークのシミュレーションを構築し，冷却に伴うイオンチャネルの反応速度の低下がてんかん発作に与える影響を検討した．","subitem_description_type":"Other"}]},"item_4_description_8":{"attribute_name":"論文抄録(英)","attribute_value_mlt":[{"subitem_description":"Focal brain cooling has been shown to suppress epileptic seizures, and it has promising applications in implantable therapeutic devices against epilepsy. However, its underlying mechanisms still remain unknown. In this study, we simulated a neocortical neuronal network using Hodgkin-Huxley-type ion channel models with temperature-dependent reaction rates, and investigated the effect of the cooling-induced decrease in reaction rate on epileptic seizures.","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"6","bibliographic_titles":[{"bibliographic_title":"研究報告バイオ情報学（BIO）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicVolumeNumber":"2013-BIO-34"}]},"relation_version_is_last":true,"weko_creator_id":"11"},"created":"2025-01-18T23:41:30.013652+00:00","id":92665,"links":{}}