{"updated":"2025-01-21T17:19:17.661754+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00087215","sets":["1164:5352:6737:6930"]},"path":["6930"],"owner":"11","recid":"87215","title":["生物医学文献情報を用いた酸化ストレス起因疾患の標的候補遺伝子データベースの構築"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-29"},"_buckets":{"deposit":"81bf58f7-5aae-4408-8b0a-063af802533e"},"_deposit":{"id":"87215","pid":{"type":"depid","value":"87215","revision_id":0},"owners":[11],"status":"published","created_by":11},"item_title":"生物医学文献情報を用いた酸化ストレス起因疾患の標的候補遺伝子データベースの構築","author_link":["0","0"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生物医学文献情報を用いた酸化ストレス起因疾患の標的候補遺伝子データベースの構築"},{"subitem_title":"Construction of a candidate target gene database for oxidative stress-induced diseases using biomedical literature","subitem_title_language":"en"}]},"item_type_id":"4","publish_date":"2012-11-29","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京理科大学大学院生命科学研究科生命科学専攻"},{"subitem_text_value":"東京理科大学薬学部生命創薬科学科"},{"subitem_text_value":"東京理科大学薬学部生命創薬科学科"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Biological Sciences, Tokyo University of Science","subitem_text_language":"en"},{"subitem_text_value":"Department of Medical and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science","subitem_text_language":"en"},{"subitem_text_value":"Department of Medical and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/87215/files/IPSJ-BIO12032022.pdf"},"date":[{"dateType":"Available","dateValue":"2014-11-29"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-BIO12032022.pdf","filesize":[{"value":"110.7 kB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"41"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"2d55e87a-5df1-4ba9-b195-b0b262cb9305","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2012 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"湯浅, 友子"},{"creatorName":"權, 娟大"},{"creatorName":"宮崎, 智"}],"nameIdentifiers":[{}]}]},"item_4_creator_6":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomoko, Yuasa","creatorNameLang":"en"},{"creatorName":"Yeondae, Kwon","creatorNameLang":"en"},{"creatorName":"Satoru, Miyazaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12055912","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"近年，酸化ストレスが生体に様々な影響を及ぼすことで，疾患の原因となっていることが分かってきた．しかし，酸化ストレス起因疾患に関連する遺伝子などの情報を提供するようなデータベースは存在しない．そのようなデータベースが構築され，その疾患だけに特有的な遺伝子が見つかれば，その遺伝子を標的とした副作用の少ない新薬開発につながる可能性がある．そこで本研究では，酸化ストレス起因疾患の新薬開発支援の観点から，疾患特有的遺伝子を順位付けして提供するデータベース検索システムを構築した．本システムで提供される酸化ストレス起因疾患関連遺伝子群は，与えられた疾患に対して特有的に関連する遺伝子群を生物医学文献から抽出し，それらの特有性に応じて順位付けするアルゴリズムにより得られたものである．酸化ストレス起因疾患名は，人手により 「酸化ストレス，活性酵素，ラジカル」 などのキーワード 20 個程を選択し，これらのキーワードを用いて文献・書籍を検索することによって網羅的な選出を試みた．","subitem_description_type":"Other"}]},"item_4_description_8":{"attribute_name":"論文抄録(英)","attribute_value_mlt":[{"subitem_description":"Recently, it has turned out that oxidative stress is the cause of a disease since it has various influences on a living body. However, there does not exist a database that provides information related to oxidative stress-induced diseases including genes. If such a database is constructed and disease-specific genes are found, it may lead to develop a new medicine of fewer side effects by setting the gene as a target. With the purpose of supporting the development of a new medicine for oxidative stress-induced diseases, we construct a database system which provides a ranked list of disease-specific genes. The genes related to oxidative stress-induced diseases which are offered by this system are obtained from an algorithm that extracts genes specific to a given disease from biomedical literature and ranks those genes according to their specificity scores. We tried to identify a comprehensive list of oxidative stress-induced disease names by choosing about 20 keywords, such as oxidative stress, reactive oxygen, and radical manually and searching literatures and books using these keywords.","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"6","bibliographic_titles":[{"bibliographic_title":"研究報告バイオ情報学（BIO）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2012-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicVolumeNumber":"2012-BIO-32"}]},"relation_version_is_last":true,"weko_creator_id":"11"},"created":"2025-01-18T23:38:03.399335+00:00","id":87215,"links":{}}