{"id":83429,"updated":"2025-01-21T18:34:35.105497+00:00","links":{},"created":"2025-01-18T23:36:55.526461+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00083429","sets":["1164:5352:6737:6844"]},"path":["6844"],"owner":"11","recid":"83429","title":["Structure-Based Drug Screening手法を用いた<i>Staphylococcus</i>属細菌に対する新規抗菌薬同定の試み"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-08-02"},"_buckets":{"deposit":"41e0d543-7aa4-4fac-b335-9a1d30ea0afb"},"_deposit":{"id":"83429","pid":{"type":"depid","value":"83429","revision_id":0},"owners":[11],"status":"published","created_by":11},"item_title":"Structure-Based Drug Screening手法を用いた<i>Staphylococcus</i>属細菌に対する新規抗菌薬同定の試み","author_link":["0","0"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structure-Based Drug Screening手法を用いた<i>Staphylococcus</i>属細菌に対する新規抗菌薬同定の試み"},{"subitem_title":"Identification of novel potential antibiotics for <i>Staphylococcus</i> by Structure-Based Drug Screening","subitem_title_language":"en"}]},"item_type_id":"4","publish_date":"2012-08-02","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"九州工業大学大学院情報工学府情報科学専攻生命情報分野"},{"subitem_text_value":"九州工業大学大学院情報工学府情報科学専攻生命情報分野"},{"subitem_text_value":"九州工業大学大学院情報工学府情報科学専攻生命情報分野"},{"subitem_text_value":"九州工業大学大学院情報工学府情報科学専攻生命情報分野"},{"subitem_text_value":"九州工業大学大学院情報工学府情報科学専攻生命情報分野"},{"subitem_text_value":"九州工業大学大学院情報工学府情報科学専攻生命情報分野／九州工業大学バイオメディカルインフォマティクス研究開発センター"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Department of Bioscience and Bioinformatics, Graduate School of Computer Science and System Engineering, Kyushu Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Bioscience and Bioinformatics, Graduate School of Computer Science and System Engineering, Kyushu Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Bioscience and Bioinformatics, Graduate School of Computer Science and System Engineering, Kyushu Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Bioscience and Bioinformatics, Graduate School of Computer Science and System Engineering, Kyushu Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Bioscience and Bioinformatics, Graduate School of Computer Science and System Engineering, Kyushu Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Bioscience and Bioinformatics, Graduate School of Computer Science and System Engineering, Kyushu Institute of Technology / Biomedical Informatics R&D Center, Kyutech Institute of Technology","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/83429/files/IPSJ-BIO12030011.pdf"},"date":[{"dateType":"Available","dateValue":"2014-08-02"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-BIO12030011.pdf","filesize":[{"value":"444.2 kB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"41"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"f8e4e8a9-9cf9-4b9c-91a2-62d80cacc178","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2012 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 舞子"},{"creatorName":"金城, 知広"},{"creatorName":"小関, 祐司"},{"creatorName":"山田, 淳美"},{"creatorName":"アリィヴァロ, 志穂"},{"creatorName":"青木, 俊介"}],"nameIdentifiers":[{}]}]},"item_4_creator_6":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maiko, Kobayashi","creatorNameLang":"en"},{"creatorName":"Tomohiro, Kinjo","creatorNameLang":"en"},{"creatorName":"Yuji, Koseki","creatorNameLang":"en"},{"creatorName":"Atsumi, Yamada","creatorNameLang":"en"},{"creatorName":"Arevalo, Shiho","creatorNameLang":"en"},{"creatorName":"Shunsuke, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12055912","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"薬剤耐性黄色ブドウ球菌に対する有効な抗菌薬の枯渇により多くの患者が世界中で亡くなっている。本研究ではstructure-based drug screening手法を用いてジヒドロ葉酸還元酵素を標的として抗菌作用を有する新規化合物の同定を試みた。その結果、黄色ブドウ球菌のモデル細菌に対して抗菌効果を有する4種類の新規化合物を同定した。またそれら化合物は腸内モデル細菌や培養哺乳類細胞に対し有意な毒性を持っていないことも確かめる事が出来た。","subitem_description_type":"Other"}]},"item_4_description_8":{"attribute_name":"論文抄録(英)","attribute_value_mlt":[{"subitem_description":"The lack of effective antibiotics against drug-resistant Staphylococcus aureus (S. aureus) is resulting in deaths of many patients all over the world. In this study, we attempted to identify novel antibiotics targeting dihydrofolate reductase by structure-based drug screening method. We identified novel 4 chemical compounds with antibacterial effects on the model bacterial strains of S. aureus. We also confirmed that the compounds do not have any toxic effects on enterobacteria and cultured mammalian cells.","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"2","bibliographic_titles":[{"bibliographic_title":"研究報告バイオ情報学（BIO）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2012-08-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicVolumeNumber":"2012-BIO-30"}]},"relation_version_is_last":true,"weko_creator_id":"11"}}