{"created":"2025-01-18T23:33:53.348438+00:00","updated":"2025-01-21T20:24:42.415344+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00078727","sets":["1164:2735:6337:6602"]},"path":["6602"],"owner":"10","recid":"78727","title":["転写因子とそのシスエレメント配列の共進化解析"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-24"},"_buckets":{"deposit":"b8fc35cf-eeac-40cf-a36d-4e2415a55406"},"_deposit":{"id":"78727","pid":{"type":"depid","value":"78727","revision_id":0},"owners":[10],"status":"published","created_by":10},"item_title":"転写因子とそのシスエレメント配列の共進化解析","author_link":["0","0"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転写因子とそのシスエレメント配列の共進化解析"},{"subitem_title":"Co-evolutionary analysis of transcription factors and cis-element sequences","subitem_title_language":"en"}]},"item_type_id":"4","publish_date":"2011-11-24","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京理科大学大学院薬学研究科薬科学専攻"},{"subitem_text_value":"東京理科大学薬学部生命創薬科学科"},{"subitem_text_value":"東京理科大学薬学部生命創薬科学科"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Pharmaceutical Sciences, Tokyo university of Science","subitem_text_language":"en"},{"subitem_text_value":"Faculty of Pharmaceutical Sciences, Tokyo University of Science","subitem_text_language":"en"},{"subitem_text_value":"Faculty of Pharmaceutical Sciences, Tokyo University of Science","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/78727/files/IPSJ-MPS11086010.pdf"},"date":[{"dateType":"Available","dateValue":"2013-11-24"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-MPS11086010.pdf","filesize":[{"value":"258.4 kB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"17"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"79a60d41-1306-427b-a5b0-be07da4720fa","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2011 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本郷, 沙妃"},{"creatorName":"權, 娟大"},{"creatorName":"宮崎, 智"}],"nameIdentifiers":[{}]}]},"item_4_creator_6":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saki, Hongo","creatorNameLang":"en"},{"creatorName":"Yeondae, Kwon","creatorNameLang":"en"},{"creatorName":"Satoru, Miyazaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10505667","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"転写因子がシスレメント配列と呼ばれる塩基配列を認識し，結合することによって，遺伝子の転写を制御している．本研究では，転写因子とシスエレメント配列の結合部位に着目し，両者には一方の配列の変化に伴い他方の配列も変化するという共進化の関係性について，配列解析による解明を試みた．まず，結合に関与する転写因子配列の進化距離を計算し進化系統樹を作成した．また該当する転写因子に認識されるシスエレメント配列の距離を情報量によって計算しクラスタリングを行った．両者のクラスタリングのトポロジーを比較することにより，両者の関係性を探索した．","subitem_description_type":"Other"}]},"item_4_description_8":{"attribute_name":"論文抄録(英)","attribute_value_mlt":[{"subitem_description":"Transcription factors regulate gene transcription by recognizing and binding the nucleotide sequences, called cis-elements. In this study, we try to clarify a relationship between transcription factors and cis-elements by focusing on binding sites of them, assuming that there exists a co-evolutionary relationship that change in one sequence causes change in another. First, we calculated the evolutionary distances of transcription factor binding sequences and created a phylogenetic tree. Next, we performed hierarchical clustering using the entropy-based distances of the cis-elements regulated by their corresponding transcription factors. Then, we analyzed a relationship between transcription factors and cis-elements by comparing the topology of the clustering results.","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"6","bibliographic_titles":[{"bibliographic_title":"研究報告数理モデル化と問題解決（MPS）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicVolumeNumber":"2011-MPS-86"}]},"relation_version_is_last":true,"weko_creator_id":"10"},"id":78727,"links":{}}