Tissue specific methylation and genotype

• Item type: SIG Technical Reports(1)
• 公開日: 2011-06-16
• タイトル: Tissue specific methylation and genotype
• タイトル / 言語: en
• タイトル: Tissue specific methylation and genotype
• 言語: eng
• キーワード / 主題Scheme: Other
• キーワード / 主題: バイオ情報学研究会・一般講演（B）
• 資源タイプ / 資源タイプ識別子: http://purl.org/coar/resource_type/c_18gh
• 資源タイプ: technical report
• 著者所属: Department of Physics, Chuo University, Tokyo, Japan
• 著者所属: Department of Physics, Chuo University, Tokyo, Japan
• 著者所属(英): en
• 著者所属(英): Department of Physics, Chuo University, Tokyo, Japan
• 著者所属(英): en
• 著者所属(英): Department of Physics, Chuo University, Tokyo, Japan
• 著者名: Ryoichi, Kinoshita; Y-H.Taguchi
• 著者名(英): Ryoichi, Kinoshita; Y-H., Taguchi
• 論文抄録 / 内容記述タイプ: Other
• 論文抄録 / 内容記述: It is unclear how genotype affects methylation. In this paper, we have applied principal component analysis to both genotype and methylation on tumor, adjacent normal tissue, and blood DNA from 30 patients. Dominant pattern turns out to be upregulation from blood to tumor through tissued for both genotype and methylation. Overlap between significantly upregulating genotype and methylized genes are significantly overlaped. Thus, at least, for some regions, genotype correlates to methylation.
• 論文抄録(英) / 内容記述タイプ: Other
• 論文抄録(英) / 内容記述: It is unclear how genotype affects methylation. In this paper, we have applied principal component analysis to both genotype and methylation on tumor, adjacent normal tissue, and blood DNA from 30 patients. Dominant pattern turns out to be upregulation from blood to tumor through tissued for both genotype and methylation. Overlap between significantly upregulating genotype and methylized genes are significantly overlaped. Thus, at least, for some regions, genotype correlates to methylation.
• 書誌レコードID / 収録物識別子タイプ: NCID
• 書誌レコードID / 収録物識別子: AA12055912
• 書誌情報: 研究報告 バイオ情報学（BIO）; 巻 2011-BIO-25, 号 39, p. 1-2, 発行日 2011-06-16
• Notice: SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc.
• 出版者 / 言語: ja
• 出版者: 情報処理学会