Search of miRNAs critical for medulloblastoma formation using MiRaGE method

• Item type: SIG Technical Reports(1)
• 公開日: 2011-06-16
• タイトル: Search of miRNAs critical for medulloblastoma formation using MiRaGE method
• タイトル / 言語: en
• タイトル: Search of miRNAs critical for medulloblastoma formation using MiRaGE method
• 言語: eng
• キーワード / 主題Scheme: Other
• キーワード / 主題: 合同企画セッション：機械学習によるバイオデータマインニング
• 資源タイプ / 資源タイプ識別子: http://purl.org/coar/resource_type/c_18gh
• 資源タイプ: technical report
• 著者所属: Department of Physics, Chuo University, Tokyo, Japan
• 著者所属: School of Medicine, Tohoku University, Sendai, Japan / Presently with Department of Cell Biology, The JFCR Cancer Institute
• 著者所属(英): en
• 著者所属(英): Department of Physics, Chuo University, Tokyo, Japan
• 著者所属(英): en
• 著者所属(英): School of Medicine, Tohoku University, Sendai, Japan / Presently with Department of Cell Biology, The JFCR Cancer Institute
• 著者名: Y-H.Taguchi; Jun, Yasuda
• 著者名(英): Y-H., Taguchi; Jun, Yasuda
• 論文抄録 / 内容記述タイプ: Other
• 論文抄録 / 内容記述: MiRaGE method estimates critical miRNAs based upon gene expression profile of their target genes. Expression profile of mRNA/miRNA is measured for tissues from neonatal and adult mice (6 days and 30 days after birth: P6 and P30, respectively), and medulloblastomas (2-3 months old: MB) with Agilent microarray is analyzed by MiRaGE method. Comparison between P30 and MB gives us the list of significantly up(down)regulated miRNAs whose target genes are down(up)regulated. The obtained list is biologically reasonable, possibly due to accuracy of Agilent microarray measurement, thus we conclude that MiRaGE method is useful to investigate tissue formation processes, too.
• 論文抄録(英) / 内容記述タイプ: Other
• 論文抄録(英) / 内容記述: MiRaGE method estimates critical miRNAs based upon gene expression profile of their target genes. Expression profile of mRNA/miRNA is measured for tissues from neonatal and adult mice (6 days and 30 days after birth: P6 and P30, respectively), and medulloblastomas (2-3 months old: MB) with Agilent microarray is analyzed by MiRaGE method. Comparison between P30 and MB gives us the list of significantly up(down)regulated miRNAs whose target genes are down(up)regulated. The obtained list is biologically reasonable, possibly due to accuracy of Agilent microarray measurement, thus we conclude that MiRaGE method is useful to investigate tissue formation processes, too.
• 書誌レコードID / 収録物識別子タイプ: NCID
• 書誌レコードID / 収録物識別子: AA12055912
• 書誌情報: 研究報告 バイオ情報学（BIO）; 巻 2011-BIO-25, 号 5, p. 1-6, 発行日 2011-06-16
• Notice: SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc.
• 出版者 / 言語: ja
• 出版者: 情報処理学会