@techreport{oai:ipsj.ixsq.nii.ac.jp:00073266,
 author = {寺田, 愛花 and 瀬々, 潤 and Aika, Terada and Jun, Sese},
 issue = {12},
 month = {Mar},
 note = {進化による変異を調べる新しい手法として，遺伝子ネットワークの種間比較がある．既存手法は，複合体やパスウエイの保存を調べる局所構造の調査であるが，進化過程では機能モジュールの組み替えの様に，局所構造に変化は無くとも大きな変化が起こる可能性が有る．本研究ではこの様な大域的な変化を同定する手法を開発し，線虫とショウジョウバエの遺伝子ネットワークを比較した結果，成長に関わるネットワークの構造は保存が高く，高次の機能は保存度が薄い事が明らかになった．, By comparison of gene networks between species, gain-of-functions in evolutional process might be found. Existing methods to compare networks focus on local network structure, and suitable for finding changes in small modules such as complexes. However, global change such as network alteration among modules may have been caused evolution. To find such global change of network, we introduce a novel method to compare gene networks. We applied our method to networks observed from C. elegans and D. melanogaster, and found that network structure related to growth are highly conserved while networks related to high-order function have little conservation.},
 title = {大域的なネットワークアラインメントを用いた遺伝子機能の比較},
 year = {2011}
}