{"links":{},"metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00066228","sets":["1164:5352:5656:5888"]},"path":["5888"],"owner":"10","recid":"66228","title":["事前知識を用いた遺伝子発現量の部分空間クラスタリング"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-10"},"_buckets":{"deposit":"90284b77-5241-40cc-be00-37fa6bd5ef4a"},"_deposit":{"id":"66228","pid":{"type":"depid","value":"66228","revision_id":0},"owners":[10],"status":"published","created_by":10},"item_title":"事前知識を用いた遺伝子発現量の部分空間クラスタリング","author_link":["0","0"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"事前知識を用いた遺伝子発現量の部分空間クラスタリング"},{"subitem_title":"Subspace clustering of gene expression data with prior knowledge","subitem_title_language":"en"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Session 3","subitem_subject_scheme":"Other"}]},"item_type_id":"4","publish_date":"2009-09-10","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"お茶の水女子大学大学院人間文化創成科学研究科"},{"subitem_text_value":"お茶の水女子大学大学院人間文化創成科学研究科"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Ochanomizu University Graduate School of Humanities and Sciences.","subitem_text_language":"en"},{"subitem_text_value":"Ochanomizu University Graduate School of Humanities and Sciences.","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/66228/files/IPSJ-BIO09018007.pdf"},"date":[{"dateType":"Available","dateValue":"2011-09-10"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-BIO09018007.pdf","filesize":[{"value":"201.9 kB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"41"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"5b835fc8-03fb-4330-9dbb-fa1077157e2a","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2009 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大村, 蓉子"},{"creatorName":"瀬々, 潤"}],"nameIdentifiers":[{}]}]},"item_4_creator_6":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoko, Omura","creatorNameLang":"en"},{"creatorName":"Jun, Sese","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12055912","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"時期，周期特異的に機能する遺伝子の発現量は，観測条件全体で相関があるのではなく，特定の時期及び周期でのみ高い相関を示すことがある．このような遺伝子群発見のため，Biclustering を始めとする部分空間クラスタリングが研究されている．しかし，既存手法にはオーバーフィットによる生成されたクラスタ信頼性の低さや，多量のクラスタ生成による結果解釈の困難さに問題点がある．そこで，近年のゲノム解析で蓄積されている遺伝子機能を用い，類似の機能を有する遺伝子から部分空間クラスタを生成し，その後，他の遺伝子へクラスタを拡張し，さらに重複を除去する事で，既知の機能に即したクラスタを発見する．遺伝子オントロジーを用いて既存手法と比較したところ，Biclustering に比べ，既知の遺伝子機能に即した遺伝子，条件群を発見できた．","subitem_description_type":"Other"}]},"item_4_description_8":{"attribute_name":"論文抄録(英)","attribute_value_mlt":[{"subitem_description":"The subspace clustering such as Biclustering has been researched for finding genes activated on specific conditions or specific cell cycles, whose gene expression levels are highly correlated only under the active conditions. However, existing methods have problems of the lack of cluster reliability caused from over-fitting and the difficulty to interpret the clusters because of the generation of numerous clusters. To overcome these problems, we generate a new method, which contains four steps: selection of functional similar genes using biological priori knowledge, generation of subspace clusters from the selected genes, enhancement of the clusters with non-selected genes, and removal of redundant clusters. Our test shows that clusters generated by our method are more correlated with Gene Ontology annotations than Biclustering.","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"7","bibliographic_titles":[{"bibliographic_title":"研究報告バイオ情報学（BIO）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2009-09-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicVolumeNumber":"2009-BIO-18"}]},"relation_version_is_last":true,"weko_creator_id":"10"},"updated":"2025-01-22T01:07:29.627095+00:00","created":"2025-01-18T23:27:06.539615+00:00","id":66228}