{"updated":"2025-01-19T07:56:51.962793+00:00","links":{},"metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00240540","sets":["1164:2036:11466:11785"]},"path":["11785"],"owner":"44499","recid":"240540","title":["量子計算を用いた機能性核酸塩基配列の導出"],"pubdate":{"attribute_name":"公開日","attribute_value":"2024-11-05"},"_buckets":{"deposit":"2a4d47ea-932c-41d7-ac11-5e5d64c64401"},"_deposit":{"id":"240540","pid":{"type":"depid","value":"240540","revision_id":0},"owners":[44499],"status":"published","created_by":44499},"item_title":"量子計算を用いた機能性核酸塩基配列の導出","author_link":["660100","660098","660099","660102","660101"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"量子計算を用いた機能性核酸塩基配列の導出"}]},"item_type_id":"4","publish_date":"2024-11-05","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"早稲田大学基幹理工学研究科"},{"subitem_text_value":"早稲田大学高等研究所"},{"subitem_text_value":"国立研究開発法人産業技術総合研究所"},{"subitem_text_value":"株式会社リボミック"},{"subitem_text_value":"早稲田大学基幹理工学研究科"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/240540/files/IPSJ-SLDM24207058.pdf","label":"IPSJ-SLDM24207058.pdf"},"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-SLDM24207058.pdf","filesize":[{"value":"1.0 MB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"0","billingrole":"10"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_login","version_id":"a77fafa3-22a8-4782-a952-0f9e83a4f62f","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2024 by the Institute of Electronics, Information and Communication Engineers This SIG report is only available to those in membership of the SIG."}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"富田, 空"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"白井, 達彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"浜田, 道昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安達, 健朗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戸川, 望"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11451459","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-8639","subitem_source_identifier_type":"ISSN"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"現在の医薬品開発では，創薬の長期化や高コスト化が問題視されている．特に次世代の医薬品として注目される中分子医薬品であるRiboNucleic Acid（RNA）アプタマーの開発が進んでいるが，膨大な配列空間を探索するには従来の計算機では限界がある．イジングマシンをはじめとするアニーリング型の量子計算機は，組合せ最適化問題をQuadratic Unconstrained Binary Optimization（QUBO）に定式化し， 基底状態を探索することで問題を求解する．イジングマシンを利用するためには，組合せ最適化問題の目的関数や制約条件をバイナリ変数の 2 次形式で表現する必要がある．本研究ではイジングマシンを活用し，Systematic Evolution of Ligands by EXponential enrichment（SELEX）実験データに基づいて最適化するための QUBO 定式化手法を提案する．実イジングマシンによる実験の結果，目的物質との結合活性がみられる塩基配列を得ることに成功した．","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"6","bibliographic_titles":[{"bibliographic_title":"研究報告システムとLSIの設計技術（SLDM）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2024-11-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"58","bibliographicVolumeNumber":"2024-SLDM-207"}]},"relation_version_is_last":true,"weko_creator_id":"44499"},"id":240540,"created":"2025-01-19T01:44:47.292516+00:00"}