{"links":{},"metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00232815","sets":["1164:2735:11468:11517"]},"path":["11517"],"owner":"44499","recid":"232815","title":["複合体構造予測とフラグメントリンキングによるPROTAC設計手法の開発"],"pubdate":{"attribute_name":"公開日","attribute_value":"2024-02-29"},"_buckets":{"deposit":"6bfa4ebb-9e42-4842-9b45-b051375e042d"},"_deposit":{"id":"232815","pid":{"type":"depid","value":"232815","revision_id":0},"owners":[44499],"status":"published","created_by":44499},"item_title":"複合体構造予測とフラグメントリンキングによるPROTAC設計手法の開発","author_link":["631096","631095"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"複合体構造予測とフラグメントリンキングによるPROTAC設計手法の開発"}]},"item_type_id":"4","publish_date":"2024-02-29","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京工業大学情報理工学院情報工学系"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/232815/files/IPSJ-MPS24147032.pdf","label":"IPSJ-MPS24147032.pdf"},"date":[{"dateType":"Available","dateValue":"2026-03-01"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-MPS24147032.pdf","filesize":[{"value":"3.4 MB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"17"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"60b12b46-f05a-4a3d-8884-4266170f3898","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2024 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石沢, 涼太"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大上, 雅史"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10505667","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-8833","subitem_source_identifier_type":"ISSN"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"ユビキチン・プロテアソーム分解系を誘導して標的タンパク質を分解する PROTAC は，従来の分子標的薬では標的とできなかったタンパク質を狙える新しい創薬モダリティである．PROTAC はリンカーと呼ばれる部位の長さや組成によって物性や分解能，標的特異性に影響を与えることがわかっている．しかし，最適なリンカーを設計する指針や方法は確立されておらず，リンカー設計のための計算技術開発が期待されている．我々は以前にフラグメントリンキング法による PROTAC リンカーの設計手法を提案した．この手法は標的タンパク質と E3 リガーゼのドッキングポーズに依存するため，本研究では標的タンパク質と E3 リガーゼの，ドッキングによる予測構造を入力構造としてリンカーを設計し，評価を行った．また，標的タンパク質，E3 リガーゼ，PROTAC の複合体構造のモデリングを行い，リンカーの比較検討を行った．","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"8","bibliographic_titles":[{"bibliographic_title":"研究報告数理モデル化と問題解決（MPS）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"32","bibliographicVolumeNumber":"2024-MPS-147"}]},"relation_version_is_last":true,"weko_creator_id":"44499"},"updated":"2025-01-19T10:18:43.895718+00:00","created":"2025-01-19T01:33:54.026856+00:00","id":232815}