Anomalous Biases of Reverse Mutations in SARS-CoV-2 Variants

• Item type: SIG Technical Reports(1)
• 公開日: 2023-11-22
• タイトル: Anomalous Biases of Reverse Mutations in SARS-CoV-2 Variants
• タイトル / 言語: en
• タイトル: Anomalous Biases of Reverse Mutations in SARS-CoV-2 Variants
• 言語: eng
• 資源タイプ / 資源タイプ識別子: http://purl.org/coar/resource_type/c_18gh
• 資源タイプ: technical report
• 著者所属: University of Tsukuba
• 著者所属: University of Tsukuba
• 著者所属(英): en
• 著者所属(英): University of Tsukuba
• 著者所属(英): en
• 著者所属(英): University of Tsukuba
• 著者名: Hideki, Kakeya; Tatsuya, Kanzaki
• 著者名(英): Hideki, Kakeya; Tatsuya, Kanzaki
• 論文抄録 / 内容記述タイプ: Other
• 論文抄録 / 内容記述: Anomalous reverse mutation patterns in the Delta variants and the Omicron variants are investigated. A previous study on the Omicron BA.1, BA.1.1, and BA.2 has found almost all the variations of sequences containing only one reverse mutation and no other point mutations, suggesting lab origin of the Omicron variant. The histograms of mutations in the spike proteins of major variants are compared, where BA.1 is outstanding in its high reverse mutation rate and low variety of mutations. Among the reverse mutations of BA.1, H681P reversion while preserving K679 is least likely to emerge naturally either through homologous recombination, point mutation, or both of them put together when the sequence alignment and mutation spectrum are taken into account. The sequences including both K679 and P681 are registered by multiple submitters, which consolidates their existence. G614D reverse mutations, a reversion of the earliest and the most dominant point mutation in SARS-CoV-2, in the Delta variant are concentrated around the Great Lakes and G614D in the BA.2 lineage are concentrated on each side of the Hudson River. To elucidate the origin of these sequences that are improbable to emerge through community spread, inspections of laboratories are needed, where the geographical distribution of anomalous sequence detections can help to narrow down the potential sources.
• 論文抄録(英) / 内容記述タイプ: Other
• 論文抄録(英) / 内容記述: Anomalous reverse mutation patterns in the Delta variants and the Omicron variants are investigated. A previous study on the Omicron BA.1, BA.1.1, and BA.2 has found almost all the variations of sequences containing only one reverse mutation and no other point mutations, suggesting lab origin of the Omicron variant. The histograms of mutations in the spike proteins of major variants are compared, where BA.1 is outstanding in its high reverse mutation rate and low variety of mutations. Among the reverse mutations of BA.1, H681P reversion while preserving K679 is least likely to emerge naturally either through homologous recombination, point mutation, or both of them put together when the sequence alignment and mutation spectrum are taken into account. The sequences including both K679 and P681 are registered by multiple submitters, which consolidates their existence. G614D reverse mutations, a reversion of the earliest and the most dominant point mutation in SARS-CoV-2, in the Delta variant are concentrated around the Great Lakes and G614D in the BA.2 lineage are concentrated on each side of the Hudson River. To elucidate the origin of these sequences that are improbable to emerge through community spread, inspections of laboratories are needed, where the geographical distribution of anomalous sequence detections can help to narrow down the potential sources.
• 書誌レコードID / 収録物識別子タイプ: NCID
• 書誌レコードID / 収録物識別子: AA12055912
• 書誌情報: 研究報告バイオ情報学（BIO）; 巻 2023-BIO-76, 号 8, p. 1-6, 発行日 2023-11-22
• ISSN / 収録物識別子タイプ: ISSN
• ISSN / 収録物識別子: 2188-8590
• Notice: SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc.
• 出版者 / 言語: ja
• 出版者: 情報処理学会