{"links":{},"metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00226506","sets":["1164:2735:11166:11285"]},"path":["11285"],"owner":"44499","recid":"226506","title":["CycPeptMPDB：包括的な環状ペプチド膜透過率データベースの開発"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-06-22"},"_buckets":{"deposit":"7a69a2ba-fa4c-4060-b07f-e812ecf0fba7"},"_deposit":{"id":"226506","pid":{"type":"depid","value":"226506","revision_id":0},"owners":[44499],"status":"published","created_by":44499},"item_title":"CycPeptMPDB：包括的な環状ペプチド膜透過率データベースの開発","author_link":["601516","601517","601521","601520","601515","601522","601519","601524","601514","601513","601518","601523"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CycPeptMPDB：包括的な環状ペプチド膜透過率データベースの開発"},{"subitem_title":"CycPeptMPDB: Development of a Comprehensive Database of Membrane Permeability of Cyclic Peptides","subitem_title_language":"en"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バイオ情報学1","subitem_subject_scheme":"Other"}]},"item_type_id":"4","publish_date":"2023-06-22","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京工業大学情報理工学院情報工学系"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系／東京工業大学中分子IT創薬研究推進体"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系／東京工業大学中分子IT創薬研究推進体"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系／東京工業大学中分子IT創薬研究推進体"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系／東京工業大学中分子IT創薬研究推進体"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系／東京工業大学中分子IT創薬研究推進体"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology / Middle Molecule IT-based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology / Middle Molecule IT-based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology / Middle Molecule IT-based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology / Middle Molecule IT-based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology / Middle Molecule IT-based Drug Discovery Laboratory (MIDL), Tokyo Institute of Technology","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/226506/files/IPSJ-MPS23143038.pdf","label":"IPSJ-MPS23143038.pdf"},"date":[{"dateType":"Available","dateValue":"2025-06-22"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-MPS23143038.pdf","filesize":[{"value":"4.0 MB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"17"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"665d52b9-dd96-4659-ba02-6c42071ed057","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2023 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"李, 佳男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柳澤, 渓甫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉田, 昌岳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤江, 拓哉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大上, 雅史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"秋山, 泰"}],"nameIdentifiers":[{}]}]},"item_4_creator_6":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jianan, Li","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Keisuke, Yanagisawa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masatake, Sugita","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takuya, Fujie","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masahito, Ohue","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yutaka, Akiyama","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10505667","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-8833","subitem_source_identifier_type":"ISSN"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"近年，環状ペプチド医薬品は，従来の低分子医薬品や抗体医薬品では狙うことが困難な細胞内タンパク質間相互作用などを標的とすることができるため，注目を集めている．しかしながら，環状ペプチドは一般的に膜透過性が低いという欠点が存在しており，経口投与や細胞内標的の阻害が可能なペプチド医薬品を開発する上での大きな課題として残っている．環状ペプチドの膜透過性を測定した研究は多く報告されているが，データを統一した形式でまとめたデータベースが未だ存在しない．そのため，本研究は 45 件の論文および 2 件の製薬企業特許から，合計 7334 件の環状ペプチドの構造および実験的に測定された膜透過性データを網羅的に収集し，世界初の環状ペプチド膜透過性データベースである CycPeptMPDB（http://cycpeptmpdb.com）として公開した．さらに，低分子化合物より複雑な環状ペプチドの構造を明確に表現するために，HELM 記法を用いて生成した全ペプチドの統一的な配列表記も収蔵されている．CycPeptMPDB は，基本的なデータストレージ機能に加えて，検索，データ分析，ダウンロードなどのいくつかのサポート機能も提供している．","subitem_description_type":"Other"}]},"item_4_description_8":{"attribute_name":"論文抄録(英)","attribute_value_mlt":[{"subitem_description":"Recently, cyclic peptide drugs have attracted much attention because they can aim targets such as intracellular protein-protein interactions that are difficult to be tackled by conventional small-molecule drugs or antibody drugs. However, cyclic peptides generally have the disadvantage of low membrane permeability. This remains a major challenge in the development of peptide drugs that can be orally administered and inhibit intracellular targets. Although there were many studies measuring the permeability of cyclic peptides, a comprehensive database that brings together these data in a unified format is not yet available. Therefore, this study collected a total of 7334 cyclic peptide structure and experimentally measured membrane permeability data comprehensively from 45 papers and 2 pharmaceutical company patents. We compiled them into CycPeptMPDB（http://cycpeptmpdb.com）, the world's first cyclic peptide membrane permeability database. To unambiguously represent structures of cyclic peptides, which are more complex than small-molecule compounds, CycPeptMPDB also contains a unified sequence representation of all peptides generated using the HELM notation. In addition to basic data storage, CycPeptMPDB provides several supporting functions such as searching, data analysis, and downloading.","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"8","bibliographic_titles":[{"bibliographic_title":"研究報告数理モデル化と問題解決（MPS）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"38","bibliographicVolumeNumber":"2023-MPS-143"}]},"relation_version_is_last":true,"weko_creator_id":"44499"},"created":"2025-01-19T01:25:57.303970+00:00","updated":"2025-01-19T12:27:20.514102+00:00","id":226506}