| Item type |
SIG Technical Reports(1) |
| 公開日 |
2022-06-20 |
| タイトル |
|
|
タイトル |
Identification of DNA Loops in the Genome by Multidimensional Scaling |
| タイトル |
|
|
言語 |
en |
|
タイトル |
Identification of DNA Loops in the Genome by Multidimensional Scaling |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_18gh |
|
資源タイプ |
technical report |
| 著者所属 |
|
|
|
Physics Major, Graduate School of Science and Engineering, Chuo University |
| 著者所属 |
|
|
|
Department of Physics, Chuo University |
| 著者所属(英) |
|
|
|
en |
|
|
Physics Major, Graduate School of Science and Engineering, Chuo University |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Physics, Chuo University |
| 著者名 |
Ryo, Ishibashi
Y-H., Taguchi
|
| 著者名(英) |
Ryo, Ishibashi
Y-H., Taguchi
|
| 論文抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The accessibility of genomic information depends on how DNA is packed into chromatin. Euchromatin is a genome region consisting of DNA with a relatively loose structure. The open structure allows RNA polymerase and other proteins to access the genome for DNA transcription. Gene expression is controlled by promotors located near the gene and gene regulatory sites called enhancers located from the gene. However, how promoters and enhancers interact with each other to regulate gene expression is not well understood. Hi-C can be used to analyze the 3D structure of a genome by detecting genomic regions that are spatially close to each other using next-generation sequencing. The conventional method led to an approximation of the genome structure from the Hi-C heatmap [1]. We demonstrated the potential of using the Hi-C method for identifying DNA loops by applying Multi-Dimensional Scaling (MDS). |
| 論文抄録(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
The accessibility of genomic information depends on how DNA is packed into chromatin. Euchromatin is a genome region consisting of DNA with a relatively loose structure. The open structure allows RNA polymerase and other proteins to access the genome for DNA transcription. Gene expression is controlled by promotors located near the gene and gene regulatory sites called enhancers located from the gene. However, how promoters and enhancers interact with each other to regulate gene expression is not well understood. Hi-C can be used to analyze the 3D structure of a genome by detecting genomic regions that are spatially close to each other using next-generation sequencing. The conventional method led to an approximation of the genome structure from the Hi-C heatmap [1]. We demonstrated the potential of using the Hi-C method for identifying DNA loops by applying Multi-Dimensional Scaling (MDS). |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10505667 |
| 書誌情報 |
研究報告数理モデル化と問題解決（MPS）
巻 2022-MPS-138,
号 53,
p. 1-5,
発行日 2022-06-20
|
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2188-8833 |
| Notice |
|
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|
SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc. |
| 出版者 |
|
|
言語 |
ja |
|
出版者 |
情報処理学会 |
IPSJ-MPS22138053.pdf (1.4 MB)
