{"created":"2025-01-19T01:17:26.250967+00:00","updated":"2025-01-19T15:41:05.326867+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00216926","sets":["1164:5352:10882:10883"]},"path":["10883"],"owner":"44499","recid":"216926","title":["新たなデータセットによる長距離フラグメントリンキング手法の再評価"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-03"},"_buckets":{"deposit":"62f5636f-0edd-4076-8e3c-dc01c1b2c477"},"_deposit":{"id":"216926","pid":{"type":"depid","value":"216926","revision_id":0},"owners":[44499],"status":"published","created_by":44499},"item_title":"新たなデータセットによる長距離フラグメントリンキング手法の再評価","author_link":["560985","560984","560986","560983"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新たなデータセットによる長距離フラグメントリンキング手法の再評価"}]},"item_type_id":"4","publish_date":"2022-03-03","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京工業大学情報理工学院情報工学系"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系"},{"subitem_text_value":"東京工業大学情報理工学院情報工学系"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology","subitem_text_language":"en"},{"subitem_text_value":"Department of Computer Science, School of Computing, Tokyo Institute of Technology","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/216926/files/IPSJ-BIO22069016.pdf","label":"IPSJ-BIO22069016.pdf"},"date":[{"dateType":"Available","dateValue":"2024-03-03"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-BIO22069016.pdf","filesize":[{"value":"6.6 MB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"41"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"675f91d8-9b87-40a5-8410-27d081819c0e","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2022 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"津嶋, 佑旗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柳澤, 渓甫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大上, 雅史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"秋山, 泰"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12055912","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-8590","subitem_source_identifier_type":"ISSN"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"フラグメントベース創薬の一手法であるフラグメントリンキングにおいて，既存の手法では長距離に対応することが難しい．そこで我々は第67回バイオ情報学研究会にて，フラグメント間の距離やドッキングスコアなどを複合した評価関数によるビームサーチで小型のリンカー要素の組み合わせを探索する手法を提案した．本研究では，5種類の異なる標的タンパク質からなるデータセットと30種類のリンカー要素を新たに作成して手法の再評価を行った．改めて手法の汎用性を確認し，実行時パラメータの最適化と独自評価関数の効果の確認を行った．","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"8","bibliographic_titles":[{"bibliographic_title":"研究報告バイオ情報学（BIO）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"16","bibliographicVolumeNumber":"2022-BIO-69"}]},"relation_version_is_last":true,"weko_creator_id":"44499"},"id":216926,"links":{}}