{"created":"2025-01-19T01:12:53.808100+00:00","updated":"2025-01-19T17:41:26.944741+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00211760","sets":["1164:2735:10526:10613"]},"path":["10613"],"owner":"44499","recid":"211760","title":["Estimation of Metabolic Effects of Cadmium Exposure during Pregnancy by Tensor Decomposition"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-21"},"_buckets":{"deposit":"2513ed1b-3bb1-42bd-8a8f-bf9c99ed40be"},"_deposit":{"id":"211760","pid":{"type":"depid","value":"211760","revision_id":0},"owners":[44499],"status":"published","created_by":44499},"item_title":"Estimation of Metabolic Effects of Cadmium Exposure during Pregnancy by Tensor Decomposition","author_link":["538607","538605","538606","538608"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Estimation of Metabolic Effects of Cadmium Exposure during Pregnancy by Tensor Decomposition"},{"subitem_title":"Estimation of Metabolic Effects of Cadmium Exposure during Pregnancy by Tensor Decomposition","subitem_title_language":"en"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バイオ情報学 (2)","subitem_subject_scheme":"Other"}]},"item_type_id":"4","publish_date":"2021-06-21","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Chuo University Faculty of Science and Engineering"},{"subitem_text_value":"Chuo University Faculty of Science and Engineering"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Chuo University Faculty of Science and Engineering","subitem_text_language":"en"},{"subitem_text_value":"Chuo University Faculty of Science and Engineering","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/211760/files/IPSJ-MPS21133026.pdf","label":"IPSJ-MPS21133026.pdf"},"date":[{"dateType":"Available","dateValue":"2023-06-21"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-MPS21133026.pdf","filesize":[{"value":"630.0 kB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"17"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"850ea459-12c2-4ba9-bac0-154034ce9678","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2021 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yuki, Amakura"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Y-H, Taguchi"}],"nameIdentifiers":[{}]}]},"item_4_creator_6":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yuki, Amakura","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Y-H, Taguchi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10505667","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-8833","subitem_source_identifier_type":"ISSN"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"studies have shown that exposure to cadmium during maternal pregnancy disrupts insulin metabolism in the unborn child. The purpose of this study is to estimate the genes actually affecting by the data obtained in this report using tensor decomposition and to speculate on the possible mechanisms of insulin metabolism disruption by these genes. By identifying genes with high expression levels, we were able to speculate on a pathway in which the effects of endoplasmic reticulum stress induced by cadmium might somehow promote increased expression of TNF-α, and the effects of intracellular oxidative stress via TNF-α-induced ceramide accumulation might lead to phosphorylation of IRS1, which plays an important role in insulin signaling. We hypothesized a pathway in which insulin resistance is acquired by phosphorylation of a protein, IRS1.","subitem_description_type":"Other"}]},"item_4_description_8":{"attribute_name":"論文抄録(英)","attribute_value_mlt":[{"subitem_description":"studies have shown that exposure to cadmium during maternal pregnancy disrupts insulin metabolism in the unborn child. The purpose of this study is to estimate the genes actually affecting by the data obtained in this report using tensor decomposition and to speculate on the possible mechanisms of insulin metabolism disruption by these genes. By identifying genes with high expression levels, we were able to speculate on a pathway in which the effects of endoplasmic reticulum stress induced by cadmium might somehow promote increased expression of TNF-α, and the effects of intracellular oxidative stress via TNF-α-induced ceramide accumulation might lead to phosphorylation of IRS1, which plays an important role in insulin signaling. We hypothesized a pathway in which insulin resistance is acquired by phosphorylation of a protein, IRS1.","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"5","bibliographic_titles":[{"bibliographic_title":"研究報告数理モデル化と問題解決（MPS）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"26","bibliographicVolumeNumber":"2021-MPS-133"}]},"relation_version_is_last":true,"weko_creator_id":"44499"},"id":211760,"links":{}}