| Item type |
SIG Technical Reports(1) |
| 公開日 |
2021-06-21 |
| タイトル |
|
|
タイトル |
Estimation of Metabolic Effects of Cadmium Exposure during Pregnancy by Tensor Decomposition |
| タイトル |
|
|
言語 |
en |
|
タイトル |
Estimation of Metabolic Effects of Cadmium Exposure during Pregnancy by Tensor Decomposition |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
バイオ情報学 (2) |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_18gh |
|
資源タイプ |
technical report |
| 著者所属 |
|
|
|
Chuo University Faculty of Science and Engineering |
| 著者所属 |
|
|
|
Chuo University Faculty of Science and Engineering |
| 著者所属(英) |
|
|
|
en |
|
|
Chuo University Faculty of Science and Engineering |
| 著者所属(英) |
|
|
|
en |
|
|
Chuo University Faculty of Science and Engineering |
| 著者名 |
Yuki, Amakura
Y-H, Taguchi
|
| 著者名(英) |
Yuki, Amakura
Y-H, Taguchi
|
| 論文抄録 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
studies have shown that exposure to cadmium during maternal pregnancy disrupts insulin metabolism in the unborn child. The purpose of this study is to estimate the genes actually affecting by the data obtained in this report using tensor decomposition and to speculate on the possible mechanisms of insulin metabolism disruption by these genes. By identifying genes with high expression levels, we were able to speculate on a pathway in which the effects of endoplasmic reticulum stress induced by cadmium might somehow promote increased expression of TNF-α, and the effects of intracellular oxidative stress via TNF-α-induced ceramide accumulation might lead to phosphorylation of IRS1, which plays an important role in insulin signaling. We hypothesized a pathway in which insulin resistance is acquired by phosphorylation of a protein, IRS1. |
| 論文抄録(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
studies have shown that exposure to cadmium during maternal pregnancy disrupts insulin metabolism in the unborn child. The purpose of this study is to estimate the genes actually affecting by the data obtained in this report using tensor decomposition and to speculate on the possible mechanisms of insulin metabolism disruption by these genes. By identifying genes with high expression levels, we were able to speculate on a pathway in which the effects of endoplasmic reticulum stress induced by cadmium might somehow promote increased expression of TNF-α, and the effects of intracellular oxidative stress via TNF-α-induced ceramide accumulation might lead to phosphorylation of IRS1, which plays an important role in insulin signaling. We hypothesized a pathway in which insulin resistance is acquired by phosphorylation of a protein, IRS1. |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10505667 |
| 書誌情報 |
研究報告数理モデル化と問題解決（MPS）
巻 2021-MPS-133,
号 26,
p. 1-5,
発行日 2021-06-21
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2188-8833 |
| Notice |
|
|
|
SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc. |
| 出版者 |
|
|
言語 |
ja |
|
出版者 |
情報処理学会 |
IPSJ-MPS21133026.pdf (630.0 kB)
