{"created":"2025-01-19T01:06:12.201289+00:00","updated":"2025-01-19T20:24:58.562467+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00203869","sets":["1164:5352:10159:10160"]},"path":["10160"],"owner":"44499","recid":"203869","title":["Sp1を標的としたHBVウィルスの新規阻害剤の探索"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-05"},"_buckets":{"deposit":"cd5522d5-39a4-453d-9e96-f998e36218e1"},"_deposit":{"id":"203869","pid":{"type":"depid","value":"203869","revision_id":0},"owners":[44499],"status":"published","created_by":44499},"item_title":"Sp1を標的としたHBVウィルスの新規阻害剤の探索","author_link":["503803","503804","503806","503805","503807"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sp1を標的としたHBVウィルスの新規阻害剤の探索"},{"subitem_title":"Development of a novel anti-hepatitis B virus agent via Sp1","subitem_title_language":"en"}]},"item_type_id":"4","publish_date":"2020-03-05","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"京都府立医科大学"},{"subitem_text_value":"中央大学"},{"subitem_text_value":"中央大学"},{"subitem_text_value":"中央大学"},{"subitem_text_value":"東京医科大学"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Kyoto Prefectural University of Medicine","subitem_text_language":"en"},{"subitem_text_value":"Chuo University","subitem_text_language":"en"},{"subitem_text_value":"Chuo University","subitem_text_language":"en"},{"subitem_text_value":"Chuo University","subitem_text_language":"en"},{"subitem_text_value":"Tokyo Medical University","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/203869/files/IPSJ-BIO20061001.pdf","label":"IPSJ-BIO20061001.pdf"},"date":[{"dateType":"Available","dateValue":"2022-03-05"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-BIO20061001.pdf","filesize":[{"value":"2.6 MB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"41"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"9f70261b-8e99-44d4-9638-d43e614d6f4e","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2020 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"早川, 路代"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梅山, 秀明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩舘, 満雄"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田口, 善弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上, 善基"}],"nameIdentifiers":[{}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12055912","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-8590","subitem_source_identifier_type":"ISSN"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"B型肝炎ウィルス（HBV）はDNA ウィルスであり，一度感染すると cccDNA と呼ばれる HBV の鋳型の DNA を完全に除去しない限り根治が難しい．本研究では HBV の増殖に必要なAlpha-glucosidase（AG）を標的とする阻害剤をインシリコで創薬し，cccDNA の削減に成功したが，奇妙なことに見つかった阻害剤は AG を標的としていなかった．そこで阻害剤をセルラインに投与した場合の発現プロファイルの解析から転写因子である SP1 が標的であることを推測して実験で確認した．","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"7","bibliographic_titles":[{"bibliographic_title":"研究報告バイオ情報学（BIO）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"2020-BIO-61"}]},"relation_version_is_last":true,"weko_creator_id":"44499"},"id":203869,"links":{}}