{"id":2000903,"updated":"2025-02-25T00:53:14.747554+00:00","links":{},"created":"2025-02-25T00:53:10.851756+00:00","metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:02000903","sets":["1164:5352:1740054670081:1740054722784"]},"path":["1740054722784"],"owner":"80578","recid":"2000903","title":["テンソル分解による糖尿病の組織特異的遺伝子発現の統合解析を用いた関連疾患の予測"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-27"},"_buckets":{"deposit":"e1126aee-cdd6-44f4-b18b-3c9cf0920b36"},"_deposit":{"id":"2000903","pid":{"type":"depid","value":"2000903","revision_id":0},"owners":[80578],"status":"published","created_by":80578},"item_title":"テンソル分解による糖尿病の組織特異的遺伝子発現の統合解析を用いた関連疾患の予測","author_link":[],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"テンソル分解による糖尿病の組織特異的遺伝子発現の統合解析を用いた関連疾患の予測","subitem_title_language":"ja"}]},"item_type_id":"4","publish_date":"2025-02-27","item_4_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"中央大学"},{"subitem_text_value":"キング・アブドゥルアズィーズ大学"}]},"item_4_text_4":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_value":"Chuo University","subitem_text_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/2000903/files/IPSJ-BIO25081005.pdf","label":"IPSJ-BIO25081005.pdf"},"date":[{"dateType":"Available","dateValue":"2027-02-27"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-BIO25081005.pdf","filesize":[{"value":"1.1 MB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"660","billingrole":"5"},{"tax":["include_tax"],"price":"330","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"41"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"ed6d90a5-3120-4264-aaf9-1d7590d98c7e","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2025 by the Information Processing Society of Japan"}]},"item_4_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田口,善弘"}]},{"creatorNames":[{"creatorName":"ターキー,ターキー"}]}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12055912","subitem_source_identifier_type":"NCID"}]},"item_4_textarea_12":{"attribute_name":"Notice","attribute_value_mlt":[{"subitem_textarea_value":"SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc."}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_18gh","resourcetype":"technical report"}]},"item_4_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-8590","subitem_source_identifier_type":"ISSN"}]},"item_4_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"遺伝子発現解析の分野では、複数の遺伝子発現プロファイルを統合する手法が依然として開発途上であり、既存の手法には改良の余地が残されています。筆者らは以前にテンソル分解を用いた教師なし特徴抽出法を提案し、標準偏差の最適化を導入して改良しました。本研究では、この改良版を用いて、複数の組織（脂肪組織、筋肉組織、肝臓組織）から取得された糖尿病の遺伝子発現プロファイルを統合解析し、従来の最先端手法では予測が難しい疾患（例えば神経変性疾患）との関連を同定できることを示しました。選択された遺伝子は個々の組織解析で得られた遺伝子とは異なるものの、3つの組織すべてで発現していることが知られています。このように、個々の組織解析と比較して、統合解析によってより深い情報が得られ、他疾患との関連が新たに明らかになる可能性があることを示します。","subitem_description_type":"Other"}]},"item_4_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"6","bibliographic_titles":[{"bibliographic_title":"研究報告バイオ情報学（BIO）"}],"bibliographicPageStart":"1","bibliographicIssueDates":{"bibliographicIssueDate":"2025-02-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicVolumeNumber":"2025-BIO-81"}]},"relation_version_is_last":true,"weko_creator_id":"80578"}}