{"metadata":{"_oai":{"id":"oai:ipsj.ixsq.nii.ac.jp:00163082","sets":["6504:8672:8724"]},"path":["8724"],"owner":"6748","recid":"163082","title":["細胞内シグナル伝達系の多安定性に関する網羅的解析"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-10"},"_buckets":{"deposit":"d3c891c7-fc61-42a6-b25a-76822a55fc9e"},"_deposit":{"id":"163082","pid":{"type":"depid","value":"163082","revision_id":0},"owners":[6748],"status":"published","created_by":6748},"item_title":"細胞内シグナル伝達系の多安定性に関する網羅的解析","author_link":["318933","318934"],"item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞内シグナル伝達系の多安定性に関する網羅的解析"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"コンピュータと人間社会","subitem_subject_scheme":"Other"}]},"item_type_id":"22","publish_date":"2016-03-10","item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_22_text_3":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"九産大"},{"subitem_text_value":"九産大"}]},"item_publisher":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"情報処理学会","subitem_publisher_language":"ja"}]},"publish_status":"0","weko_shared_id":-1,"item_file_price":{"attribute_name":"Billing file","attribute_type":"file","attribute_value_mlt":[{"url":{"url":"https://ipsj.ixsq.nii.ac.jp/record/163082/files/IPSJ-Z78-4E-02.pdf","label":"IPSJ-Z78-4E-02.pdf"},"date":[{"dateType":"Available","dateValue":"2016-05-19"}],"format":"application/pdf","billing":["billing_file"],"filename":"IPSJ-Z78-4E-02.pdf","filesize":[{"value":"659.3 kB"}],"mimetype":"application/pdf","priceinfo":[{"tax":["include_tax"],"price":"0","billingrole":"6"},{"tax":["include_tax"],"price":"0","billingrole":"8"},{"tax":["include_tax"],"price":"0","billingrole":"44"}],"accessrole":"open_date","version_id":"59910a63-ddc7-47d7-a899-fd386629508d","displaytype":"detail","licensetype":"license_note","license_note":"Copyright (c) 2016 by the Information Processing Society of Japan"}]},"item_22_creator_5":{"attribute_name":"著者名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"末吉, 智奈佐"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"仲, 隆"}],"nameIdentifiers":[{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourceuri":"http://purl.org/coar/resource_type/c_5794","resourcetype":"conference paper"}]},"item_22_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00349328","subitem_source_identifier_type":"NCID"}]},"item_22_description_7":{"attribute_name":"論文抄録","attribute_value_mlt":[{"subitem_description":"　細胞内シグナル伝達系は，細胞内の生化学反応を制御しており，その異常が細胞のがん化の原因と考えられているため，近年盛んに研究されている．しかし，生化学反応は非線形であるため，理論的解析手法の構築が難しい．系毎にパラメータを固定したシミュレーション解析が行われているのが現状である．　本研究では，シグナル伝達系を，伝達経路の酵素の活性化不活性化サイクル反応をノードとし，その制御関係をアークとする制御ネットワークとして定式化することにより，系の多安定性に関する網羅的解析を行った．ネットワークを構成する各ノードは，活性化と不活性化の最大反応速度の比というパラメータを持つ．ネットワークの形状と制御関係に加え，このパラメータについても網羅的な解析を行った．","subitem_description_type":"Other"}]},"item_22_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageEnd":"430","bibliographic_titles":[{"bibliographic_title":"第78回全国大会講演論文集"}],"bibliographicPageStart":"429","bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"2016"}]},"relation_version_is_last":true,"weko_creator_id":"6748"},"id":163082,"updated":"2025-01-20T11:27:43.288202+00:00","links":{},"created":"2025-01-19T00:35:03.757539+00:00"}