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  1. 研究報告
  2. 数理モデル化と問題解決(MPS)
  3. 2014
  4. 2014-MPS-098

TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer

https://ipsj.ixsq.nii.ac.jp/records/101819
https://ipsj.ixsq.nii.ac.jp/records/101819
5573c183-a0bd-44bb-9f8a-9b51ee08148e
名前 / ファイル ライセンス アクション
IPSJ-MPS14098008.pdf IPSJ-MPS14098008.pdf (1.0 MB)
Copyright (c) 2014 by the Information Processing Society of Japan
オープンアクセス
Item type SIG Technical Reports(1)
公開日 2014-06-18
タイトル
タイトル TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer
タイトル
言語 en
タイトル TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer
言語
言語 eng
キーワード
主題Scheme Other
主題 合同企画セッション:バイオデータマイニング
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_18gh
資源タイプ technical report
著者所属
Department of Biological Science, Chuo University
著者所属
Department of Biological Science, Chuo University
著者所属
Department of Physics, Chuo University
著者所属(英)
en
Department of Biological Science, Chuo University
著者所属(英)
en
Department of Biological Science, Chuo University
著者所属(英)
en
Department of Physics, Chuo University
著者名 Hideaki, Umeyama Mitsuo, Iwadate Y-h.Taguchi

× Hideaki, Umeyama Mitsuo, Iwadate Y-h.Taguchi

Hideaki, Umeyama
Mitsuo, Iwadate
Y-h.Taguchi

Search repository
著者名(英) Hideaki, Umeyama Mitsuo, Iwadate Y-h., Taguchi

× Hideaki, Umeyama Mitsuo, Iwadate Y-h., Taguchi

en Hideaki, Umeyama
Mitsuo, Iwadate
Y-h., Taguchi

Search repository
論文抄録
内容記述タイプ Other
内容記述 Background: Non-small cell lung cancer (NSCLC) remains lethal despite the development of numerous drug therapy technologies. About 85% to 90% of lung cancers are NSCLC and the 5-year survival rate is at best still below 50%. Thus, it is important to find drug target genes for NSCLC to develop an effective therapy for NSCLC. Results: Integrated analysis of publically available gene expression and promoter methylation patterns of two highly aggressive NSCLC cell lines generated by in vivo selection was performed. We selected eleven critical genes that may mediate metastasis using recently proposed principal component analysis based unsupervised feature extraction. The eleven selected genes were significantly related to cancer diagnosis. The tertiary protein structure of the selected genes were inferred by Full Automatic Modeling System, a profile based protein structure inference software, to determine protein functions and to specify genes that could be potential drug targets. Conclusions: We identified eleven potentially critical genes that may mediate NSCLC metastasis using bioinformatic analysis of publically available data sets. These genes are potential target genes for therapy of NSCLC. Among the eleven genes, TINAGL1 and B3GALNT1 are possible candidates for drug compounds that inhibit their gene expression.
論文抄録(英)
内容記述タイプ Other
内容記述 Background: Non-small cell lung cancer (NSCLC) remains lethal despite the development of numerous drug therapy technologies. About 85% to 90% of lung cancers are NSCLC and the 5-year survival rate is at best still below 50%. Thus, it is important to find drug target genes for NSCLC to develop an effective therapy for NSCLC. Results: Integrated analysis of publically available gene expression and promoter methylation patterns of two highly aggressive NSCLC cell lines generated by in vivo selection was performed. We selected eleven critical genes that may mediate metastasis using recently proposed principal component analysis based unsupervised feature extraction. The eleven selected genes were significantly related to cancer diagnosis. The tertiary protein structure of the selected genes were inferred by Full Automatic Modeling System, a profile based protein structure inference software, to determine protein functions and to specify genes that could be potential drug targets. Conclusions: We identified eleven potentially critical genes that may mediate NSCLC metastasis using bioinformatic analysis of publically available data sets. These genes are potential target genes for therapy of NSCLC. Among the eleven genes, TINAGL1 and B3GALNT1 are possible candidates for drug compounds that inhibit their gene expression.
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN10505667
書誌情報 研究報告数理モデル化と問題解決(MPS)

巻 2014-MPS-98, 号 8, p. 1-6, 発行日 2014-06-18
Notice
SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc.
出版者
言語 ja
出版者 情報処理学会
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