Possible miRNA coreguation of target genes in brain regions by both differential miRNA expression and miRNA-targeting-specific promoter methylation

• Item type: SIG Technical Reports(1)
• 公開日: 2013-03-14
• タイトル: Possible miRNA coreguation of target genes in brain regions by both differential miRNA expression and miRNA-targeting-specific promoter methylation
• タイトル / 言語: en
• タイトル: Possible miRNA coreguation of target genes in brain regions by both differential miRNA expression and miRNA-targeting-specific promoter methylation
• 言語: eng
• キーワード / 主題Scheme: Other
• キーワード / 主題: 遺伝子制御・ネットワーク
• 資源タイプ / 資源タイプ識別子: http://purl.org/coar/resource_type/c_18gh
• 資源タイプ: technical report
• 著者所属: Department of Physics, Chuo University
• 著者所属(英): en
• 著者所属(英): Department of Physics, Chuo University
• 著者名: Y-H.Taguchi
• 著者名(英): Y-H., Taguchi
• 論文抄録 / 内容記述タイプ: Other
• 論文抄録 / 内容記述: We computationally reanalysed public domain data set deposited to gene expression omnibus, of mRNA expression, miRNA expression and promoter methylation pattern in four brain regions, i.e., frontal cortex, temporal cortex, pons and cerebellum. Then we found that more than hundreds of both miRNA regulation of target genes and miRNA-targeting-specific promoter methylation are significant on all six pairwise comparisons among the above mentioned four brain regions. We also showed that some of miRNA regulation of target genes are highly correlated with both or either of miRNA-targeting-specific promoter methylation and differential miRNA expression. We concluded that the combinatorial analysis of miRNA regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can figure out brain region specific contribution of miRNAs to brain functions and developments.
• 論文抄録(英) / 内容記述タイプ: Other
• 論文抄録(英) / 内容記述: We computationally reanalysed public domain data set deposited to gene expression omnibus, of mRNA expression, miRNA expression and promoter methylation pattern in four brain regions, i.e., frontal cortex, temporal cortex, pons and cerebellum. Then we found that more than hundreds of both miRNA regulation of target genes and miRNA-targeting-specific promoter methylation are significant on all six pairwise comparisons among the above mentioned four brain regions. We also showed that some of miRNA regulation of target genes are highly correlated with both or either of miRNA-targeting-specific promoter methylation and differential miRNA expression. We concluded that the combinatorial analysis of miRNA regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can figure out brain region specific contribution of miRNAs to brain functions and developments.
• 書誌レコードID / 収録物識別子タイプ: NCID
• 書誌レコードID / 収録物識別子: AA12055912
• 書誌情報: 研究報告バイオ情報学（BIO）; 巻 2013-BIO-33, 号 6, p. 1-6, 発行日 2013-03-14
• Notice: SIG Technical Reports are nonrefereed and hence may later appear in any journals, conferences, symposia, etc.
• 出版者 / 言語: ja
• 出版者: 情報処理学会